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The carbonic anydrase inhibitors, acetazolamide, brimzolamide and dorzolamide, reduce intraocular pressure by reducing aqueous humour production. Systemic use of acetazolamide also produces weak diuresis. Acetazolamide is given orally , it is used as an adjunct to toher treatment but is not generally recommended for long term use due to side effects, these include metabolic acidosis and electrolyte imbalance; renal calculi; parasthesia; headach and malaise; GI upset; blood dyscrasias. |