Formulary Chapter 15: Anaesthesia - Full Chapter
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Notes: |
The development of this chapter for the George Eliot Formulary is in progress |
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Details... |
15.01 |
General anaesthesia |
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15.01.01 |
Intravenous anaesthetics |
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Thiopental
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Formulary
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- Available as 500mg injection
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15.01.01 |
Other intravenous anaesthetics |
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Etomidate
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Formulary
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- Available as 20mg/10ml injection
- Etomidate should only be administered by, or under the direct supervision of, personnel experienced in its use, with adequate training in anaesthesia and airway management, and when resuscitation equipment is available
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Ketamine injection (Ketalar®)
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Formulary
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- Available as 500mg/10mL injection
- Ketamine should only be administered by, or under the direct supervision of, personnel experienced in its use, with adequate training in anaesthesia and airway management, and when resuscitation equipment is available
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Propofol
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Formulary
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- Available as:
- 1000mg/100mL
- 200mg/20mL
- 500mg/50mL
- Propofol should only be administered by, or under the direct supervision of, personnel experienced in its use, with adequate training in anaesthesia and airway management, and when resuscitation equipment is available
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15.01.02 |
Inhalational anaesthetics |
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15.01.02 |
Volatile liquid anaesthetics |
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Isoflurane
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Formulary
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- Available as inhalation vapour (250mL bottle)
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Sevoflurane
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Formulary
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- Available as volatile liquid (250mL bottle)
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15.01.03 |
Antimuscarinic drugs |
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Atropine
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Formulary
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- Available as:
- 600micrograms/1mL
- 1mg/5mL (for cardiac boxes)
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Glycopyrronium (injection)
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Formulary
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- Available as:
- 200mcg/mL injection
- 600mcg/3mL injection
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Hyoscine Hydrobromide (injection)
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Formulary
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15.01.04 |
Sedative and analgesic peri-operative drugs |
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15.01.04.01 |
Benzodiazepines |
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15.01.04.01 |
Benzodiazepines |
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Benzodiazepines possess useful properties for pre-medication including relief of anxiety, sedation and amnesia; short-acting benzodiazepines taken by mouth are the most common premedicants. Benzodiazepines are also used in intensive care units for sedation, particularly in those receiving assisted ventilation. Flumazenil is used to antagonise the effects of benzodiazepines.
Diazepam is used to produce mild sedation with amnesia. It is a long-acting drug with active metabolites and a second period of drowsiness can occur several hours after its administration. Temazepam is given by mouth for premedication and has a shorter duration of action and a more rapid onset than oral diazepam; anxiolytic and sedative effects last about 90 minutes although there may be residual drowsiness. Lorazepam produces more prolonged sedation than temazepam and it has marked amnesic effects. Midazolam is a water-soluble benzodiazepine that is often used in preference to intravenous diazepam; recovery is faster than from diazepam, but may be significantly longer in the elderly, in patients with low cardiac output, or after repeated dosing. |
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Diazepam (pre-med)
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Formulary
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- Available as:
- Tablets 2mg & 10mg
- Injection 10mg/2mL
- Oral solution 2mg/5mL
- See Chapter 4 for rectal use in epilepsy
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Lorazepam (pre-med)
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Formulary
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- Available as:
- Tablets will dissolve under the tongue if the patients has a sufficiently moist mouth and tablets can be dispersed in water
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Midazolam (pre-med)
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Formulary
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- Available as injection
- 10mg/2mL (palliative care/EoL)
- 10mg/5mL
- 5mg/5mL
- See Chapter 4 for buccal use in epilepsy
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Temazepam (pre-med)
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Formulary
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15.01.04.02 |
Non-opioid analgesics |
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Ketorolac (Toradol®) (postoperative pain)
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Formulary
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- Available as injection 30mg/mL
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15.01.04.03 |
Opioid analgesics |
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Opiod analgesics given in small doses before or with induction reduce the dose requirement of some drugs used during anaesthesia. Alfentanil, fentanyl and remifentanyl are particularly useful because they act within 1-2 minutes and have short duration of action. |
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Alfentanil
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Formulary
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- Available as injection 1mg/2mL & 5mg/10mL
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Fentanyl (injection)
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Formulary
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- Available as injection 0.1mg/2mL
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Remifentanil
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Formulary
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- Available as injection 1mg & 5mg
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15.01.04.04 |
Other drugs for sedation |
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Dexmedetomidine (Dexdor®)
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Formulary
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- Available as injection 200mcg/2mL & 400mcg/2mL
- Dexmedetomidine should only be administered by, or under the direct supervision of, personnel experienced in its use, with adequate training in anaesthesia and airway management.
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15.01.05 |
Neuromuscular blocking drugs |
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15.01.05 |
Non-depolarising muscle relaxants |
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Atracurium Besilate (Tracrium®)
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Formulary
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Mivacurium Chloride (Mivacron®)
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Formulary
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Rocuronium Bromide (Esmeron®)
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Formulary
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15.01.05 |
Depolarising muscle relaxants |
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Suxamethonium Chloride
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Formulary
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15.01.06 |
Drugs for reversal of neuromuscular blockade |
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15.01.06 |
Anticholinesterases |
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Neostigmine
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Formulary
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Neostigmine with Glycopyrronium
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Formulary
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15.01.06 |
Other drugs for reversal of neuromuscular blockade |
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Sugammadex (Bridion®)
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Formulary
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15.01.07 |
Antagonists for central and respiratory depression |
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Doxapram (Dopram®)
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Formulary
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Flumazenil (Anexate®)
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Formulary
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Naloxone
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Formulary
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15.01.08 |
Drugs for malignant hyperthermia |
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Dantrolene Sodium (Dantrium Intravenous®)
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Formulary
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Chloroprocaine Hydrochloride 10mg/ml (Ampres ®)
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Formulary
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Ampoules
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15.02 |
Bupivacaine |
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Bupivacaine hydrochloride (Marcain®)
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Formulary
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- Available as 0.25% & 0.5% injection
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Bupivacaine Hydrochloride with Glucose (Marcain Heavy®)
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Formulary
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Bupivacaine with Fentanyl
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Formulary
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- Available as injection (bupivacaine 0.125% with fentanyl 2mcg/mL 240mL bag)
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Levobupivacaine (Chirocaine®)
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Formulary
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- Available as:
- 0.25% (2.5mg/1mL) injection
- 0.5% (5mg/1mL) injection
- 0.75% (7.5mg/1mL) injection
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Levobupivacaine with Fentanyl
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Formulary
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- Available as levobupivacaine 0.1% with fentanyl 2mcg/mL 100mL bag - Epidural
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Lidocaine (topical solution)
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Formulary
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- Available as 4% topical solution 25mL
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Lidocaine (ointment)
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Formulary
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- Available as 5% ointment 15g
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Lidocaine (injection)
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Formulary
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- Available as 1% & 2% injection
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Lidocaine (spray)
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Formulary
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- Available as 10mg per actuation spray
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Lidocaine 2.5% with Prilocaine 2.5% (EMLA®)
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Formulary
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- Available as cream 5g and 30g
- Contraindicated in child less than 37 weeks corrected gestational age
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Lidocaine 5% and Phenylephrine 0.5% (topical solution)
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Formulary
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- Available as topical solution with nasal applicator
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Lidocaine with Adrenaline (Lignospan®)
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Formulary
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- Available as lidocaine 2% with adrenaline 1 in 80000 injection
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Lidocaine with Adrenaline (Xylocaine®)
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Formulary
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- Available as:
- lidocaine 1% with adrenaline 1 in 200000 injectin
- lidocaine 2% with adrenaline 1 in 200000 injection
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Lidocaine2% with Chlorhexidine 0.25% (Instillagel®)
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Formulary
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- Available as gel 6mL and 11mL
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Prilocaine Hydrochloride
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Formulary
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- Available as 1% and 2% injection
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15.02 |
Procaine |
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Ropivacaine 0.2% and 10ml of 0.75% in 200ml infusion bag
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Formulary
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At George Eliot Hospital there has been a surge in regional anaesthesia and more and more patients are being offered regional anaesthesia for their procedures. The advantage of procedures being carried out under regional block is that they don’t need to sit in recovery bay and can be discharged faster with a much quicker recovery rate.
Ropivacaine offers a faster return of Motor function with effective onset and duration of sensory block. A faster return of motor function will allow patients to mobilise faster therefore leading to a quicker discharge time and will represent a significant cost saving.
There are specific orthopaedic procedures such as upper limb trauma cases, where consultant Orthopaedic surgeons are requesting local anaesthesia blocks which provide only sensory analgesia with little or no motor block, this enables surgeons to assess motor power of the upper limbs immediately following surgery.
Nerve catheters are now also in use on wards for abdominal surgery and rib fractures and this will allow patients to mobilise faster leading to a quicker recovery time, reduced risk of DVT and shorter hospital stay.
George Eliot Hospital NHS Trust are currently in the process of developing a method for undertaking total knee replacement as a day case procedure, Ropivacaine would be most suitable for thi.
- BMC Anesthesiol. 2019 Jun 29:19(1): 114. Doi 10.1186/s12871-019-0787-6
Continuous Adductor Canal Block used for postoperative pain relief after medial Unicondylar Knee Arthroplasty: a randomised, double blind, placebo controlled trial.
- J Anaesthesiol Clin Pharmacol. 2019 Jan-Mar:35(1):41-46. doi: 10.4103/joacp.JOACP_70_18.
The estimation of minimum effective volume of 0.5% Ropivacaine in ultrasound-guided interscalene brachial plexus nerve block: A clinical trial.
- J Clin Diagn Res. 2015 Jan; 9(1): UCO1-UC06. Comparison between Bupivacaine and Ropivacaine in
patients undergoing forearm surgeries under axillary brachial plexus block: A prospective randomised study Anupreet Kaur¹, Raj Bahadur Singh², R.K.Tripathi², and Sanjay Choubey²
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Tetracaine (Amethocaine) (Ametop®)
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Formulary
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- Available as 4% gel
- Licensed from > 1month old
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15.02 |
Other local anaesthetics |
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Ethyl Chloride (Axongesic® Spray)
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Formulary
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Mepivacaine (Scandonest Plain®)
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Formulary
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- Available as 3% injection
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Non Formulary Items |
Propofol 2% injection in 50ml (Only for Theatres and ITU)

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Non Formulary
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50ml vial |
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Key |
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Cytotoxic Drug
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Controlled Drug
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High Cost Medicine
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Cancer Drugs Fund
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NHS England |
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Homecare |
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CCG |
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Traffic Light Status Information
Status |
Description |

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SPECIALIST ONLY - These drugs are deemed to be not appropriate for prescribing by GPs. Specialists should not ask GPs to prescribe these drugs. |

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SPECIALIST INITIATED - These drugs must be initiated, i.e. the first dose prescribed, by the specialist and then may be continued when appropriate by the patients GP following communication from the specialist. |

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SPECIALIST ADVISED – Specialists may simply advise a patients GP to initiate these drugs themselves after they have made an initial assessment. |

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SHARED CARE - Responsibility for prescribing may be transferred from secondary to primary care with the agreement of an individual GP and when agreed shared care arrangements have been established. The specialist MUST stabilize the patient before asking for care to be transferred. Only specialists should initiate these drugs. Prescribing should be transferred to GPs according to an Shared Care Agreement [SCA] |
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