Bisphosphonates have an important role in the prophylaxis and treatment of osteoporosis and corticosteroid induced osteoporosis.
Tablets should be swallowed whole with plenty of water while sitting or standing, on an empty stomach at least 30 minutes before breakfast (or other medicine); patient should stand or sit upright for at least 30 minutes after administration.
Patients (or their carers) should be advised to stop taking and to seek medical attention if they develop symptoms of oesophageal irritation such as dysphagia, new or worsening heartburn, pain on swallowing or retrosternal pain.
MHRA/CHM ADVICE: Bisphosphonates: Atypical femoral fractures - patients should be advised to report any thigh, hip or groin pain during treatment with a bisphosphonate.
MHRA/CHM ADVICE: Bisphosphonates: Osteonecrosis of the jaw - during bisphosphonate treatment patients shold maintain good oral hygeine, receive routine dental check-ups, and report any oral symptoms.
MHRA/CHM ADVICE: Bisphosphonates: Osteonecrosis of the exernal auditory canal - patients should be advised to report any ear pain, discharge from ear or an ear infection during treatment with a bisphosphonate.