Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
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Notes: |
The development of this chapter for the George Eliot Formulary is in progress |
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Details... |
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08.01 |
Side-effects of cytotoxic drugs |
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08.01 |
Drugs for cytotoxic-induced side-effects |
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Dexrazoxane
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Formulary
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Folinic acid (as calcium folinate)
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Formulary
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Mesna
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Formulary
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08.01.01 |
Alkylating drugs |
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Bendamustine
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Formulary
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for relapsed low grade lymphoma and relapsed multiple myeloma (Bendamustine is not licensed in these indications)
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NICE TA216: Bendamustine for the first-line treatment of chronic lymphocytic leukaemia
NICE TA472: Obinutuzumab with bendamustine for treating follicular lymphoma refractory to rituximab
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Chlorambucil
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Formulary
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Cyclophosphamide
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Formulary
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Dacarbazine
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Formulary
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Melphalan
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Formulary
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08.01.02 |
Anthracyclines and other cytotoxic antibiotics |
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Bleomycin
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Formulary
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Doxorubicin Hydrochloride
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Formulary
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Epirubicin hydrochloride
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Formulary
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Mitomycin
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Formulary
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Pixantrone
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Formulary
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NICE TA306: Pixantrone monotherapy for treating multiply relapsed or refractory aggressive non-Hodgkin's B‑cell lymphoma
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Azacitidine (Vidaza®)
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Formulary
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NICE TA218: Azacitidine for the treatment of myelodysplastic syndromes, chronic myelomonocytic leukaemia and acute myeloid leukaemia
NICE TA399: Azacitidine for treating acute myeloid leukaemia with more than 30% bone marrow blasts
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Capecitabine (Xeloda®)
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Formulary
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NICE TA100: Capecitabine and oxaliplatin in the adjuvant treatment of stage III (Dukes’ C) colon cancer
NICE TA191: Capecitabine for the treatment of advanced gastric cancer
NICE TA212: Bevacizumab in combination with oxaliplatin and either fluorouracil plus folinic acid or capecitabine for the treatment of metastatic colorectal cancer
NICE TA263: Bevacizumab in combination with capecitabine for the first-line treatment of metastatic breast cancer
NICE TA61: Guidance on the use of capecitabine and tegafur with uracil for metastatic colorectal cancer
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Cladribine
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Formulary
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NICE TA493: Cladribine tablets for treating relapsing–remitting multiple sclerosis
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Cytarabine
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Formulary
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Fludarabine Phosphate (Fludara®)
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Formulary
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NICE TA119: Fludarabine monotherapy for the first-line treatment of chronic lymphocytic leukaemia
NICE TA29: Guidance on the use of fludarabine for B-cell chronic lymphocytic leukaemia
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Fluorouracil
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Formulary
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NICE TA212: Bevacizumab in combination with oxaliplatin and either fluorouracil plus folinic acid or capecitabine for the treatment of metastatic colorectal cancer
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Gemcitabine (Gemzar®)
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Formulary
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NICE TA116: Gemcitabine for the treatment of metastatic breast cancer
NICE TA25: Pancreatic cancer - gemcitabine
NICE TA476: Paclitaxel as albumin-bound nanoparticles with gemcitabine for untreated metastatic pancreatic cancer
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Mercaptopurine
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Formulary
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Methotrexate
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Formulary
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UKMI Q&A: alcohol and methotrexate guidance
UKMI Q&A: What is the clinical significance of the interaction between methotrexate and penicillins? (Oct13)
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Pemetrexed (Alimta®)
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Formulary
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NICE TA124: Pemetrexed for the treatment of non-small-cell lung cancer
NICE TA135: Pemetrexed for the treatment of malignant pleural mesothelioma
NICE TA181: Pemetrexed for the first-line treatment of non-small-cell lung cancer
NICE TA190: Pemetrexed for the maintenance treatment of non-small-cell lung cancer
NICE TA309: Lung cancer (non small cell, non squamous) - pemetrexed
NICE TA402: Pemetrexed maintenance treatment for non-squamous non-small-cell lung cancer after pemetrexed and cisplatin
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Trifluridine with tipiracil (Lonsurf®)
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Formulary
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NICE TA405: Trifluridine–tipiracil for previously treated metastatic colorectal cancer
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08.01.04 |
Vinca alkaloids and etoposide |
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Etoposide
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Formulary
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Vinblastine Sulphate
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Formulary
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Vincristine Sulphate
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Formulary
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Vinorelbine
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Formulary
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08.01.05 |
Monoclonal antibodies |
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Nivolumab (Opdivo®)
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Formulary
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NICE TA384: Nivolumab for treating advanced (unresectable or metastatic) melanoma
NICE TA400: Nivolumab in combination with ipilimumab for treating advanced melanoma
NICE TA417: Nivolumab for previously treated advanced renal cell carcinoma
NICE TA462: Nivolumab for treating relapsed or refractory classical Hodgkin lymphoma
NICE TA483: Nivolumab for previously treated squamous non-small-cell lung cancer
NICE TA484: Nivolumab for previously treated non-squamous non-small-cell lung cancer
NICE TA490: Nivolumab for treating squamous cell carcinoma of the head and neck after platinum-based chemotherapy
NICE TA530: Nivolumab for treating locally advanced unresectable or metastatic urothelial cancer after platinum-containing chemotherapy
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08.01.06 |
Other antineoplastic drugs |
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Aflibercept (Zaltrap®)
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Formulary
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NICE TA294: Aflibercept solution for injection for treating wet age‑related macular degeneration
NICE TA305: Aflibercept for treating visual impairment caused by macular oedema secondary to central retinal vein occlusion
NICE TA307: Aflibercept in combination with irinotecan and fluorouracil-based therapy for treating metastatic colorectal cancer that has progressed following prior oxaliplatin-based chemotherapy
NICE TA346: Aflibercept for treating diabetic macular oedema
NICE TA486: Aflibercept for treating choroidal neovascularisation
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Atezolizumab (Tecentriq®)
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Formulary
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NICE TA492: Atezolizumab for untreated PD-L1-positive locally advanced or metastatic urothelial cancer when cisplatin is unsuitable
NICE TA520: Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after chemotherapy
NICE TA525: Atezolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
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Daratumumab (Darzalex®)
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Formulary
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NICE TA510: Daratumumab monotherapy for treating relapsed and refractory multiple myeloma
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Eribulin (Halaven®)
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Formulary
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for NICE TA423
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NICE TA423: Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens
NICE TA515: Eribulin for treating locally advanced or metastatic breast cancer after 1 chemotherapy regimen
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Panobinostat (Farydak®)
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Formulary
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NICE TA380: Panobinostat for treating multiple myeloma after at least 2 previous treatments
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Pertuzumab (Perjeta®)
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Formulary
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NICE TA424: Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancer
NICE TA509: Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer
Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancer
Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer
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Procarbazine
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Formulary
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Raltitrexed (Tomudex®)
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Formulary
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Tivozanib (Fotivda®)
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Formulary
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NICE TA512: Tivozanib for treating advanced renal cell carcinoma
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Venetoclax (Venclyxto)
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Formulary
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NICE TA487: Venetoclax for treating chronic lymphocytic leukaemia
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08.01.06 |
Bevacizumab |
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Bevacizumab (Avastin®)
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Formulary
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for first line treatment of recurrent or metastatic cervical cancer in combination with chemotherapy, third line treatment of glioma in childhood and first line treatment of advanced epithelial ovarian, fallopian tube or primary peritoneal cancer.
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NICE TA118: Bevacizumab and cetuximab for the treatment of metastatic colorectal cancer
NICE TA178: Bevacizumab (first-line), sorafenib (first- and second-line), sunitinib (second-line) and temsirolimus (first-line) for the treatment of advanced and/or metastatic renal cell carcinoma
NICE TA212: Bevacizumab in combination with oxaliplatin and either fluorouracil plus folinic acid or capecitabine for the treatment of metastatic colorectal cancer
NICE TA214: Bevacizumab in combination with a taxane for the first-line treatment of metastatic breast cancer
NICE TA214: Breast Cancer with taxane
NICE TA242: Cetuximab, bevacizumab and panitumumab for the treatment of metastatic colorectal cancer after first-line chemotherapy
NICE TA263: Bevacizumab in combination with capecitabine for the first-line treatment of metastatic breast cancer
NICE TA284: Bevacizumab in combination with paclitaxel and carboplatin for first-line treatment of advanced ovarian cancer
NICE TA285: Bevacizumab in combination with gemcitabine and carboplatin for treating the first recurrence of platinum-sensitive advanced ovarian cancer
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Bortezomib (Velcade®)
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Formulary
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for the treatment of bortezomib naive relapsed multiple myeloma
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NICE TA129: Bortezomib monotherapy for relapsed multiple myeloma
NICE TA228: Bortezomib and thalidomide for the first-line treatment of multiple myeloma
NICE TA299: Leukaemia (chronic myeloid) - bosutinib
NICE TA311: Bortezomib for induction therapy in multiple myeloma before high-dose chemotherapy and autologous stem cell transplantation
NICE TA370: Bortezomib for previously untreated mantle cell lymphoma
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08.01.06 |
Brentuximab vedotin |
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Brentuximab vedotin (Adcetris®)
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Formulary
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for relapsed or refractory CD30+ Hodgkin's lymphona after at least 2 previous therapies and cannot have autologous stem cell translplant or multi-agent chemotherapy
for relapsed or refractory CD30+ Hodgkin's lymphona after autologous stem cell transplant and for relapsed or refractory systemic large cell lymphoma
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NICE TA478: Brentuximab vedotin for treating relapsed or refractory systemic anaplastic large cell lymphoma
NICE TA524: Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma
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Cetuximab (Erbitux®)
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Formulary
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NICE TA118: Bevacizumab and cetuximab for the treatment of metastatic colorectal cancer
NICE TA145: Cetuximab for the treatment of locally advanced squamous cell cancer of the head and neck
NICE TA172: Head and neck cancer (squamous cell carcinoma) - cetuximab
NICE TA176: Colorectal cancer (first line) - cetuximab
NICE TA242: Cetuximab, bevacizumab and panitumumab for the treatment of metastatic colorectal cancer after first-line chemotherapy
NICE TA439: Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
NICE TA473: Cetuximab for treating recurrent or metastatic squamous cell cancer of the head and neck
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08.01.06 |
Hydroxycarbamide |
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Hydroxycarbamide
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Formulary
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08.01.06 |
Panitumumab |
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Panitumumab (Vectibix®)
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Formulary
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NICE TA242: NICE TA242: Cetuximab, bevacizumab and panitumumab for the treatment of metastatic colorectal cancer after first-line chemotherapy
NICE TA439: Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
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Pentostatin (Nipent®)
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Formulary
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08.01.06 |
Platinum compounds |
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Carboplatin
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Formulary
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Cisplatin
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Formulary
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Oxaliplatin
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Formulary
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NICE TA100: Capecitabine and oxaliplatin in the adjuvant treatment of stage III (Dukes’ C) colon cancer
NICE TA212: Bevacizumab in combination with oxaliplatin and either fluorouracil plus folinic acid or capecitabine for the treatment of metastatic colorectal cancer
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08.01.06 |
Porfimer sodium and temoporfin |
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08.01.06 |
Protein kinase inhibitors |
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Axitinib (Inlyta®)
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Formulary
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NICE TA333: Axitinib for treating advanced renal cell carcinoma after failure of prior systemic treatment
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Bosutinib (Bosulif®)
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Formulary
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NICE TA401: Bosutinib for previously treated chronic myeloid leukaemia
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Cabozantinib (Cometriq® Cabometyx®)
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Formulary
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NICE TA463: Cabozantinib for previously treated advanced renal cell carcinoma
NICE TA516: Cabozantinib for treating medullary thyroid cancer
NICE TA542: Cabozantinib for untreated advanced renal cell carcinoma
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Crizotinib (Xalkori®)
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Formulary
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for NICE TA529 if the conditions in the managed access agreement are followed.
for NICE TA406 and NICE TA422
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NICE TA406: Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
NICE TA422: Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
NICE TA529: Crizotinib for treating ROS1-positive advanced non-small-cell lung cancer
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Dasatinib (Sprycel®)
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Formulary
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for NICE TA426
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NICE TA241: CML for whom treatment with imatinib has failed because of intolerance
NICE TA251: Leukaemia (chronic myeloid, first line) - dasatinib, nilotinib and standard-dose imatinib
NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
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Everolimus (Afinitor®)
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Formulary
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for NICE TA421, TA432 and TA449
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NICE TA219: Everolimus for second-line treatment of renal cell cancer
NICE TA295: Breast cancer (HER2 negative, oestrogen receptor positive, locally advanced or metastatic) - everolimus (with an aromatase inhibitor):
NICE TA348: Everolimus for preventing organ rejection in liver transplantation
NICE TA421: Everolimus with exemestane for treating advanced breast cancer after endocrine therapy
NICE TA432: Everolimus for advanced renal cell carcinoma after previous treatment
NICE TA449: Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
NICE TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
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Gefitinib (Iressa®)
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Formulary
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NICE TA192: Gefitinib for the first-line treatment of locally advanced or metastatic non-small-cell lung cancer
NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
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Ibrutinib (Imbruvica®)
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Formulary
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NICE TA429: Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation
NICE TA491: Ibrutinib for treating Waldenstrom’s macroglobulinaemia
NICE TA502: Ibrutinib for treating relapsed or refractory mantle cell lymphoma
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Imatinib (Gilvec®)
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Formulary
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NICE TA196: Gastrointestinal stromal tumours - imatinib (adjuvant): guidance
NICE TA209: Imatinib for the treatment of unresectable and/or metastatic gastrointestinal stromal tumours
NICE TA241: Leukaemia (chronic myeloid) - dasatinib, nilotinib, imatinib (intolerant, resistant)
NICE TA251: Leukaemia (chronic myeloid, first line) - dasatinib, nilotinib and standard-dose imatinib
NICE TA326: Imatinib for the adjuvant treatment of gastrointestinal stromal tumours
NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
NICE TA70: Guidance on the use of imatinib for chronic myeloid leukaemia
NICE TA86: Imatinib for the treatment of unresectable and/or metastatic gastro-intestinal stromal tumours
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Lenvatinib (Kisplyx®)
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Formulary
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NICE TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
NICE TA535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
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Nilotinib (Tasigna®)
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Formulary
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NICE TA241: Dasatinib, nilotinib and high dose imatinib for CML
NICE TA251: Leukaemia (chronic myeloid, first line) - dasatinib, nilotinib and standard-dose imatinib
NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
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Osimertinib (Tagrisso®)
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Formulary
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NICE TA416: Osimertinib for treating locally advanced or metastatic EGFR T790M mutation-positive non-small-cell lung cancer
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Palbociclib (Ibrance®)
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Formulary
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NICE TA495: Palbociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
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Pazopanib (Votrient®)
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Formulary
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NICE TA215: Pazopanib for the first-line treatment of advanced renal cell carcinoma
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Ruxolitinib (Jakavi®)
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Formulary
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NICE TA386: Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis
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Sorafenib (Nexavar®)
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Formulary

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NICE TA178: Bevacizumab (first-line), sorafenib (first- and second-line), sunitinib (second-line) and temsirolimus (first-line) for the treatment of advanced and/or metastatic renal cell carcinoma
NICE TA189: Hepatocellular carcinoma (advanced and metastatic) - sorafenib (first line)
NICE TA474: Sorafenib for treating advanced hepatocellular carcinoma
NICE TA535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
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Sunitinib (Sutent®)
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Formulary
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NICE TA169: Sunitinib for the first-line treatment of advanced and/or metastatic renal cell carcinoma
NICE TA178: Bevacizumab (first-line), sorafenib (first- and second-line), sunitinib (second-line) and temsirolimus (first-line) for the treatment of advanced and/or metastatic renal cell carcinoma
NICE TA179: Sunitinib for the treatment of gastrointestinal stromal tumours
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Temsirolimus (Torisel®)
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Formulary
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NICE TA178: Bevacizumab (first-line), sorafenib (first- and second-line), sunitinib (second-line) and temsirolimus (first-line) for the treatment of advanced and/or metastatic renal cell carcinoma
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Vemurafenib (Zelboraf®)
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Formulary
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NICE TA269: Vemurafenib for treating locally advanced or metastatic BRAF V600 mutation‑positive malignant melanoma
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08.01.06 |
Taxanes |
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Cabazitaxel (Jevtana®)
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Formulary
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NICE TA391: Cabazitaxel for hormone-relapsed metastatic prostate cancer treated with docetaxel
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Docetaxel
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Formulary
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NICE TA101: Docetaxel for the treatment of hormone-refractory metastatic prostate cancer
NICE TA109: Breast cancer (early) - docetaxel
NICE TA509: Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer
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Paclitaxel
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Formulary
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NICE TA108: Breast cancer (early) - paclitaxel
NICE TA55: Guidance on the use of paclitaxel in the treatment of ovarian cancer
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Paclitaxel albumin (Abraxane®)
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Formulary
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NICE TA476: Paclitaxel as albumin-bound nanoparticles with gemcitabine for untreated metastatic pancreatic cancer
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08.01.06 |
Topoisomerase I inhibitors |
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Irinotecan Hydrochloride
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Formulary
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NICE TA440: Pegylated liposomal irinotecan for treating pancreatic cancer after gemcitabine
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Topotecan
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Formulary
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NICE TA183: Topotecan for the treatment of relapsed small-cell lung cancer
NICE TA184: Topotecan for the treatment of relapsed small-cell lung cancer
NICE TA389: Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
NICE TA91: Ovarian cancer (advanced) - paclitaxel, pegylated liposomal doxorubicin hydrochloride and topotecan (review)
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Trastuzumab (Herzuma®)
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Formulary
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- When prescribing, dispensing or administering, check that this is the correct preparation - trastuzumab emtansine and trastuzumab are NOT interchangeable.
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NICE TA107: Breast cancer (early) - trastuzumab
NICE TA208: Trastuzumab for the treatment of HER2-positive metastatic gastric cancer
NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
NICE TA257: Lapatinib or trastuzumab in combination with an aromatase inhibitor for the first-line treatment of metastatic hormone-receptor-positive breast cancer that overexpresses HER2
NICE TA34: Guidance on the use of trastuzumab for the treatment of advanced breast cancer
NICE TA509: Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer
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Trastuzumab emtansine (Kadcyla®)
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Formulary
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- When prescribing, dispensing or administering, check that this is the correct preparation - trastuzumab emtansine and trastuzumab are NOT interchangeable.
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NICE TA458: Trastuzumab emtansine for treating HER2-positive advanced breast cancer after trastuzumab and a taxane
Trastuzumab emtansine for treating HER2-positive advanced breast cancer after trastuzumab and a taxane
Trastuzumab emtansine for treating HER2-positive, unresectable locally advanced or metastatic breast cancer after treatment with trastuzumab and a taxane
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08.01.06 |
Vismodegib |
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08.02 |
Drugs affecting the immune response |
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08.02 |
Immunosuppressant therapy |
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08.02.01 |
Antiproliferative immunosuppressants |
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Azathioprine
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Formulary
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UKMI Q&A: Can mothers breast feed while taking azathioprine?
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Mycophenolate Mofetil
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Formulary
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08.02.02 |
Corticosteroids and other immunosuppressants |
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08.02.03 |
Anti-lymphocyte monoclonal antibodies |
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Obinutuzumab (Gazyvaro®)
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Formulary
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NICE TA343: Obinutuzumab in combination with chlorambucil for untreated chronic lymphocytic leukaemia
NICE TA472: Obinutuzumab with bendamustine for treating follicular lymphoma refractory to rituximab
NICE TA513: Obinutuzumab for untreated advanced follicular lymphoma
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Ofatumumab (Arzerra®)
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Formulary
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NICE TA202: Ofatumumab for the treatment of chronic lymphocytic leukaemia refractory to fludarabine and alemtuzumab
NICE TA344: Ofatumumab in combination with chlorambucil or bendamustine for untreated chronic lymphocytic leukaemia
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Rituximab (Truxima® MabThera®)
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Formulary
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NICE TA110: Follicular lymphoma - rituximab Non-Hodgkin's lymphoma - rituximab
NICE TA137: Rituximab for the treatment of relapsed or refractory stage III or IV follicular non-Hodgkin’s lymphoma
NICE TA174:Rituximab for the first-line treatment of chronic lymphocytic leukaemia
NICE TA193: Rituximab for the treatment of relapsed or refractory chronic lymphocytic leukaemia
NICE TA226: Lymphoma (follicular non-Hodgkin’s) - rituximab
NICE TA243: Rituximab for the first-line treatment of stage III-IV follicular lymphoma
NICE TA65: Non-Hodgkin’s lymphoma - rituximab
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08.02.04 |
Other immunomodulating drugs |
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Lenalidomide
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Formulary
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NICE TA171: Lenalidomide for the treatment of multiple myeloma in people who have received at least one prior therapy
NICE TA322: Lenalidomide for treating myelodysplastic syndromes associated with an isolated deletion 5q cytogenetic abnormality
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Pomalidomide (Imnovid®)
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Formulary
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NICE TA427: Pomalidomide for multiple myeloma previously treated with lenalidomide and bortezomib
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Thalidomide
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Formulary
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NICE TA228: Bortezomib and thalidomide for the first‑line treatment of multiple myeloma
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BCG bladder instillation (OncoTICE®)
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Formulary
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08.02.04 |
Glatiramer acetate |
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08.03 |
Sex hormones and hormone antagonists in malignant disease |
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Diethylstilbestrol
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Formulary
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Ethinylestradol
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Formulary
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Medroxyprogesterone Acetate
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Formulary
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Megestrol Acetate (Megace®)
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Formulary
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Norethisterone
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Formulary
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08.03.03 |
Androgens |
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08.03.04 |
Hormone antagonists |
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08.03.04.01 |
Breast cancer |
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Anastrozole (Arimidex®)
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Formulary
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Exemestane
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Formulary
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NICE TA421: Everolimus with exemestane for treating advanced breast cancer after endocrine therapy
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Fulvestrant (Faslodex®)
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Formulary
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NICE TA239: Fulvestrant for the treatment of locally advanced or metastatic breast cancer
NICE TA503: Fulvestrant for untreated locally advanced or metastatic oestrogen-receptor positive breast cancer
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Goserelin-Zoladex®
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Formulary
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Tamoxifen
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Formulary
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08.03.04.02 |
Prostate cancer and gonadorelin analogues |
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08.03.04.02 |
Gonadorelin analogues |
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Degarelix (Firmagon®)
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Formulary
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08.03.04.02 |
Anti-androgens |
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Abiraterone (Zytiga®)
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Formulary
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NICE TA259: Abiraterone for castration-resistant metastatic prostate cancer previously treated with a docetaxel-containing regimen
NICE TA387: Abiraterone for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicated
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Bicalutamide
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Formulary
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Cyproterone Acetate
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Formulary
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Enzalutamide (Xtandi®)
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Formulary
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NICE TA316: Enzalutamide for metastatic hormone‑relapsed prostate cancer previously treated with a docetaxel‑containing regimen
NICE TA377: Enzalutamide for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicated
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Goserelin (Zoladex®)
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Formulary
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Goserelin (Zoladex® LA)
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Formulary
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Leuprorelin Acetate 3.75mg (Prostap® SR)
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Formulary
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Triptorelin- Decapeptyl® SR 3mg
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Formulary
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08.03.04.03 |
Somatostatin analogues |
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.... |
Key |
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Cytotoxic Drug
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Controlled Drug
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High Cost Medicine
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Cancer Drugs Fund
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NHS England |
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Homecare |
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CCG |
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Traffic Light Status Information
Status |
Description |

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SPECIALIST ONLY - These drugs are deemed to be not appropriate for prescribing by GPs. Specialists should not ask GPs to prescribe these drugs. |

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SPECIALIST INITIATED - These drugs must be initiated, i.e. the first dose prescribed, by the specialist and then may be continued when appropriate by the patients GP following communication from the specialist. |

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SPECIALIST ADVISED – Specialists may simply advise a patients GP to initiate these drugs themselves after they have made an initial assessment. |

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SHARED CARE - Responsibility for prescribing may be transferred from secondary to primary care with the agreement of an individual GP and when agreed shared care arrangements have been established. The specialist MUST stabilize the patient before asking for care to be transferred. Only specialists should initiate these drugs. Prescribing should be transferred to GPs according to an Shared Care Agreement [SCA] |
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